Quality you can verify

A Certificate of Analysis (COA) is a document issued by an independent laboratory verifying that a product meets its chemical specifications. For peptides, the key parameters are:

1. HPLC Purity: Measured using High-Performance Liquid Chromatography. This indicates the percentage of target peptide molecule relative to chemical impurities. Prism enforces a strict >99% standard.

2. Mass Identification: Conducted via Mass Spectrometry. This confirms the molecular mass matches the theoretical sequence, proving the chemical identity of the compound.

HPLC is an analytical chemistry technique used to separate, identify, and quantify each component in a mixture. The sample is pushed under high pressure through a column packed with adsorbent material. Different molecules interact differently with the column material, causing them to exit (elute) at different times (retention times).

A detector records the eluting molecules as peaks on a chromatogram. The area under the main peak relative to the total peak area determines the overall purity percentage.

While HPLC tells us how pure a substance is, it cannot definitively prove *what* the substance is. Mass Spectrometry (MS) measures the mass-to-charge ratio (m/z) of ionized molecules. This lets researchers determine the exact molecular weight of the peptide.

By comparing the measured mass to the theoretical molecular weight of the peptide sequence, the laboratory confirms identity with absolute structural certainty.

We test every single synthesis batch without exception. Peptide synthesis occurs in discrete batches (lots). Purity can fluctuate from one synthesis run to another due to coupling efficiency. To guarantee clinical-grade consistency, we test every newly synthesized lot through independent laboratories before packaging and distribution.